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Prostate Cancer Targeting with 7E11-C5.3—CdS Bioconjugated Quantum Dots

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The aim of this study was to conjugate water-soluble CdS quantum dots (QDs) suitable for targeting of human prostate cancer cells. The water—soluble QDs were conjugated with transferring (Tf) or the murine monoclonal antibody, 7E11-C5.3 through the free carboxylic groups covalently attached. The conjugated CdS were characterized by luminescence and Bradford assay to confirm the attachment of the molecules on the surface of the semiconductor nanocrystals. Cytotoxicity studies showed increased cell viability of the conjugated QDs compared to plain QDs. The conjugates were used to label LNCaP prostate cancer cells and after 5 hr incubation were localized in the cell nucleus. The results showed that QD—7E11 conjugates could be used for in vivo diagnostic studies.
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Keywords: BIOCONJUGATION; MONOCLONAL ANTIBODY; PROSTATE CANCER; TRANSFERRIN; WATER SOLUBLE QUANTUM DOTS

Document Type: Research Article

Publication date: March 1, 2013

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  • Journal of Colloid Science and Biotechnology is an international multidisciplinary peer- reviewed journal covering all aspects of colloid science including colloids preparation, characterization, structure-property relationships, spectroscopy, chemical and physical properties and applications of colloids in biotechnology, medicine and pharmaceuticals. This journal deals with interdisciplinary research areas of chemistry, physics, biology, materials science, polymer science, nanotechnology covering all topics related to colloids such as latexes, emulsions, suspensions, micellar systems, gels, composites, hybrids, surfactants, aerosols, foams, minerals, soft matter, microfluidics, encapsulation processes of active molecules, biomolecules, surfacial and interfacial processes, catalysis, electrochemistry, theoretical aspects, computer simulations and colloids in biotechnology and medicine.
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