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Hydrophilic and Fluorescent Colloidal Nanorods of MWNTs as Effective Targeted Drug Carrier

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In this article, a new method for fabrication of multi-walled carbon nanotubes (MWNTs) nanorods as targeted drug carrier has been reported. Firstly, the MWNTs were effectively cut off to short MWNTs (s-MWNTs) nanorods by a mastication of rubber/MWNTs mixture, then the s-MWNTs were covalently functionalized with hydrophilic branched polymer, these hydrophilic s-MWNTs (hs-MWNTs) showed excellent colloidal stability in water. Finally, the fluorescent tag and folic acid were attached to the end of the polymer chains on the surface of hs-MWNTs (f-MWNTs). After loading the anticancer drug of podophyllotoxin (PPT), the PPT-loaded f-MWNTs (f-MWNTs-PPT) displayed very high cytotoxicity against Hela cells and low cytotoxicity against 293T cell compared with free PPT. At the concentration of 40 g/mL, the Hela cell viability treated with f-MWNTs-PPT was 37%, while that of pure PPT showed 72%. This result clearly showed that the f-MWNTs drug delivery system was more selective and effective, and it has great potential as practical drug carriers.
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Keywords: COLLOIDAL STABILITY; CYTOTOXICITY; DRUG CARRIER; FLUORESCENT TAG; MULTI-WALLED CARBON NANOTUBES (MWNTS)

Document Type: Research Article

Publication date: December 1, 2012

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  • Journal of Colloid Science and Biotechnology is an international multidisciplinary peer- reviewed journal covering all aspects of colloid science including colloids preparation, characterization, structure-property relationships, spectroscopy, chemical and physical properties and applications of colloids in biotechnology, medicine and pharmaceuticals. This journal deals with interdisciplinary research areas of chemistry, physics, biology, materials science, polymer science, nanotechnology covering all topics related to colloids such as latexes, emulsions, suspensions, micellar systems, gels, composites, hybrids, surfactants, aerosols, foams, minerals, soft matter, microfluidics, encapsulation processes of active molecules, biomolecules, surfacial and interfacial processes, catalysis, electrochemistry, theoretical aspects, computer simulations and colloids in biotechnology and medicine.
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