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Effect of Bio Function Enhanced-Dual TiO2 Nanotube Implants on Osseointegration: A Comparative Study in Rabbit Model

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The purpose of this study is to evaluate the effect of dual TiO2 nanotube implant on osseointegration in rabbit. A dual TiO2 nanotube implant, consisting of various combinations of two different nanotube sizes, was divided into four groups: 8 nm/30 nm, 8 nm/70 nm, 30 nm/70 nm, and 30 nm/100 nm TiO2 nanotube. A total of 40 dual TiO2 nanotube implants were fabricated and implanted to the tibia of rabbits, which were then sacrificed after 2 and 12 weeks. The level of osseointegration was compared among the groups throughout the radiologic, histological, and histomorphometric analysis. The micro-CT analysis results showed that the bone volume (BV) value (%) of 12-week group was higher than that of 2-week group overall, and 8/30 group within the 2-week group and 30/100 group within the 12-week group displayed the highest BV value (p > 0.05). The histologic and histomorphometric analysis also showed that the recession (%) around the micro-thread was significantly lower in the 12-week group than in the 2-week group (p < 0.05), and 8/70 group within the 2-week group and 30/70 group and 30/100 group within the 12-week group presented the lowest value. The area of the new bone (μm2) formed above upper cortical bone border was the largest in 30/70 group within the 2-week group and in 30/100 group within the 12-week group (p > 0.05). The bone to implant contact (BIC) value (%) measured within the bone marrow exhibited that 8/30 group in the 2-week group and 8/70 group in the 12-week group had the highest (p > 0.05), while the BV value (%) measured within the marrow revealed that 30/100 groups in both of 2-week and 12-week groups had the highest (p > 0.05).
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Document Type: Research Article

Publication date: June 1, 2018

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  • Journal of Biomaterials and Tissue Engineering (JBT) is an international peer-reviewed journal that covers all aspects of biomaterials, tissue engineering and regenerative medicine. The journal focuses on the broad spectrum of research topics including all types of biomaterials, their properties, bioimplants and medical devices, biofilms, bioimaging, BioMEMS/NEMS, biosensors, fibers, tissue scaffolds, tissue engineering and modeling, artificial organs, tissue interfaces, interactions between biomaterials, blood, cells, tissues, and organs, regenerative medicine and clinical performance.
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