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Modification of Poly(methyl methacrylate) Bone Cement for Vertebroplasty

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The treatments of spinal bone destruction, such as vertebral compressive fracture, vertebral tumor caused by external trauma, or metastatic tumor require vertebroplasty with bone cement. Research and development of bone cement with easy operability, good biosafety and biocompatibility, and appropriate mechanical strength is an important issue for clinical requirements. Poly(methyl methacrylate) (PMMA) bone cement are the earliest and most widely used bone cement product, as their safety and clinical effects have been generally recognized. A relatively high compressive modulus, very low biocompatibility, and lack of osteointegration caused by the bioinert properties of PMMA has limited the long-term outcomes and further developments of PMMA-based bone cements. Since the disadvantages of the PMMA bone cement are known, the modification of these cements has become a very active area of research. In the present work, we will review the progress of strategies and their effects on the modification of PMMA bone cement used for vertebroplasty, with focus on new approaches, such as addition of biocompatible and bioactive materials, as well as their clinical applications and performance evaluations. At the end of this review, future development directions and prospects of PMMA bone cement are discussed.
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Keywords: BIOCOMPATIBILITY; MECHANICAL PROPERTIES; MINERALIZED COLLAGEN; MODIFICATION; OSTEOINTEGRATION; PMMA BONE CEMENT

Document Type: Review Article

Publication date: May 1, 2018

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  • Journal of Biomaterials and Tissue Engineering (JBT) is an international peer-reviewed journal that covers all aspects of biomaterials, tissue engineering and regenerative medicine. The journal focuses on the broad spectrum of research topics including all types of biomaterials, their properties, bioimplants and medical devices, biofilms, bioimaging, BioMEMS/NEMS, biosensors, fibers, tissue scaffolds, tissue engineering and modeling, artificial organs, tissue interfaces, interactions between biomaterials, blood, cells, tissues, and organs, regenerative medicine and clinical performance.
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