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Nattokinase Crude Extract Enhances Cutaneous Wound Healing

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Nattokinase (NK) is a fibrinolytic enzyme produced by Bacillus subtilis. This enzyme comes from a traditional Japanese fermented food called natto, and has therapeutic effects in a variety of diseases including hypertension, Alzheimer's disease, and vitreoretinal disorders. Whether NK is effective in skin tissue regeneration is unclear. Using ultrafiltration membranes, we separated a cultured medium of Bacillus subtilis into samples of different molecular weights. Of all the components from the cultured medium of Bacillus subtilis, only the 10 kDa (K) to 100 K molecular weight components had NK activity; these components were named nattokinase crude extract (NCE). NCE demonstrated the ability to promote wound healing in mouse skin-resection injuries. Relative to the other ingredients in the cultured supernatant, NCE has a more pronounced effect on epidermal regeneration and angiogenesis. The expression levels of Oct-4 and Nanog in the skin tissue of the NCE-treated group were significantly higher. This study reveals a new role for NK in cutaneous wound healing and demonstrates that NCE extends the application of NK.
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Document Type: Research Article

Publication date: December 1, 2017

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  • Journal of Biomaterials and Tissue Engineering (JBT) is an international peer-reviewed journal that covers all aspects of biomaterials, tissue engineering and regenerative medicine. The journal focuses on the broad spectrum of research topics including all types of biomaterials, their properties, bioimplants and medical devices, biofilms, bioimaging, BioMEMS/NEMS, biosensors, fibers, tissue scaffolds, tissue engineering and modeling, artificial organs, tissue interfaces, interactions between biomaterials, blood, cells, tissues, and organs, regenerative medicine and clinical performance.
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