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Evaluation of Bone Regeneration Following Combination Therapy with Platelet-Rich Plasma and Chitosan/Hydroxyapatite

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Background. Increasing attention has been paid to platelet-rich plasma (PRP) as an adjunct to aid bone healing. Combining bone graft substitutes with PRP is a promising approach to reduce the reliance on autografts. The aim of this study was to evaluate the combination of PRP with a chitosan/hydroxyapatite (CS/HA) scaffold to promote bone regeneration in a rabbit model. Methods. Sixteen adult rabbits were included in this randomized, prospective study. Bone defects measuring 10 × 5 mm2 were created in the middle shaft of the radius. The defects were treated with void, PRP, artificial bone substitute (CS/HA) and PRP + CS/HA. The animals were sacrificed at 12 weeks. Bone regeneration was assessed by radiographical, histological and immunohistochemical (COL I and OC) analyses. Results. The platelet concentration of the PRP was 4.45-fold higher than that of the peripheral whole blood. Twelve weeks after surgery, the PRP + CS/HA group showed much more bone formation than the other groups on the basis of the radiological, histological and gross findings. However, the immunohistochemical analyses indicated no significant difference among the groups. Conclusions. The PRP and the CS/HA and PRP + CS/HA scaffolds showed osteogenic regeneration in the rabbit radius defect model. The study demonstrated a synergistic enhancing effect between the PRP and the CS/HA scaffold.
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Keywords: BONE DEFECT; BONE REGENERATION; CHITOSAN/HYDROXYAPATITE (CS/HA); PLATELET-RICH PLASMA (PRP)

Document Type: Research Article

Publication date: August 1, 2017

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  • Journal of Biomaterials and Tissue Engineering (JBT) is an international peer-reviewed journal that covers all aspects of biomaterials, tissue engineering and regenerative medicine. The journal focuses on the broad spectrum of research topics including all types of biomaterials, their properties, bioimplants and medical devices, biofilms, bioimaging, BioMEMS/NEMS, biosensors, fibers, tissue scaffolds, tissue engineering and modeling, artificial organs, tissue interfaces, interactions between biomaterials, blood, cells, tissues, and organs, regenerative medicine and clinical performance.
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