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Fe3O4 @MnO2 @PAA Nanoparticles for Magnetically Targeted Microwave-Thermal Therapy Guided by Thermoacoustic Imaging

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The strategy of selectively destroy cancer cells and sparing normal tissue is highly desirable during the cancer therapy. In this paper, magnetic targeted microwave thermal therapy was demonstrated by the integration of MnO2 and Fe3O4 nanoparticles, where MnO2 shell efficiently converted microwave into heat and Fe3O4 nanoparticles served as target moiety directed by external magnetic field to tumor site. The polyacrylic acid (PAA) functionalized Fe3O4 @MnO2 nanoparticles were prepared by simple two step method. And the as-obtained Fe3O4 @MnO2 @PAA exhibit low toxicity in vitro. Specifically, the Fe3O4 @MnO2 @PAA can be applied as a microwave-induced thermoacoustic imaging agent due to their strong microwave absorption. Furthermore, we demonstrate an effective result for magnetically targeted microwave-thermal ablation of cancer. All these results show a great potential for localized microwave-thermal ablation of cancer timely guided by the magnetic field and indicated the promise of the multifunctional Fe3O4 @MnO2 @PAA nanoparticles for applications in cancer theranostics.
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Keywords: FE3O4 @MNO2 @PAA; MAGNETIC TARGET; MICROWAVE-THERMAL THERAPY; THERMO-ACOUSTIC IMAGING

Document Type: Research Article

Publication date: January 1, 2016

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  • Journal of Biomaterials and Tissue Engineering (JBT) is an international peer-reviewed journal that covers all aspects of biomaterials, tissue engineering and regenerative medicine. The journal focuses on the broad spectrum of research topics including all types of biomaterials, their properties, bioimplants and medical devices, biofilms, bioimaging, BioMEMS/NEMS, biosensors, fibers, tissue scaffolds, tissue engineering and modeling, artificial organs, tissue interfaces, interactions between biomaterials, blood, cells, tissues, and organs, regenerative medicine and clinical performance.
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