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In Vivo Performance of Poly(ε-caprolactone) Constructs Loaded with Gentamicin Releasing Composite Microspheres for Use in Bone Regeneration

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For materials used in the production of dental and orthopedic implants or scaffolds for bone tissue regeneration, the properties such as capacity to enhance cell attachment and proliferation, and antimicrobial activity to prevent biofilm formation are very important to improve the clinical utility of the material. In this study, poly(ε-caprolactone) (PCL) sponges with antimicrobial activity were prepared by incorporating gentamicin loaded β-tricalcium phosphate (β-TCP)-Gelatin microspheres, andin vivo performances were studied. These composite systems are expected to enhance bone regeneration due to β-TCP and prevent a possible infection by releasing gentamicin in the host location. The effects of gentamicin and β-TCP/Gelatin microspheres in the sponge structure were studiedin vivo by applying them on iliac crest defects of rabbits. Histological analyses after 8 weeks of implantation showed that the composite constructs performed significantly better in bone healing than those with antibiotic-free microspheres. Also, the PCL constructs carrying β-TCP/Gelatin microspheres led to better bone formation than the pristine PCL scaffolds. Push-out tests demonstrated better integration of the constructs with the tissue indicating high level of material-tissue integration. This study indicates the importance of the presence of antibiotics and β-TCP/Gelatin in the scaffolds to achieve better and faster healing in bone defects than pristine scaffolds.
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Keywords: GELATIN; GENTAMICIN; MICROSPHERES; POLY(ε-CAPROLACTONE); β-TRICALCIUM PHOSPHATE

Document Type: Research Article

Publication date: October 1, 2014

More about this publication?
  • Journal of Biomaterials and Tissue Engineering (JBT) is an international peer-reviewed journal that covers all aspects of biomaterials, tissue engineering and regenerative medicine. The journal focuses on the broad spectrum of research topics including all types of biomaterials, their properties, bioimplants and medical devices, biofilms, bioimaging, BioMEMS/NEMS, biosensors, fibers, tissue scaffolds, tissue engineering and modeling, artificial organs, tissue interfaces, interactions between biomaterials, blood, cells, tissues, and organs, regenerative medicine and clinical performance.
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