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Enhanced Degradation and Osteogenesis of β-Tricalcium Phosphate/Calcium Sulfate Composite Bioceramics: The Effects of Phase Ratio

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The β-TCP/CaS composites were hydrothermal synthesized at various ratios using bovine trabecular bone and CaS (CaSO4 ยท 2H2O) powder. The performance of the composites degradation as well as osteogenesis were then evaluated in vitro and in vivo. It was shown that the β-TCP/CaS composites overcame the drawback of β-TCP (degrading too slowly) and CaS (degrading too fast). Furthermore, the in vitro and in vivo degradation rates of the composites increased with increasing CaS. It was also shown that combining CaS and TCP enhanced the osteogenic activities, most likely due to a better match between the rates of degradation and new bone formation. Furthermore, the composites had a self-setting feature, which benefited the defect repair with complex-shapes. Our study further suggested that β-TCP/CaS composites could be a useful substitute for the bone defect therapy with the phase ratio as an important factor affecting the performance of TCP/CaS composite bioceramics.
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Keywords: BIOCERAMICS; BONE; CALCIUM SULFATE; COMPOSITE MATERIAL; TRICALCIUM PHOSPHATE

Document Type: Research Article

Publication date: May 1, 2014

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  • Journal of Biomaterials and Tissue Engineering (JBT) is an international peer-reviewed journal that covers all aspects of biomaterials, tissue engineering and regenerative medicine. The journal focuses on the broad spectrum of research topics including all types of biomaterials, their properties, bioimplants and medical devices, biofilms, bioimaging, BioMEMS/NEMS, biosensors, fibers, tissue scaffolds, tissue engineering and modeling, artificial organs, tissue interfaces, interactions between biomaterials, blood, cells, tissues, and organs, regenerative medicine and clinical performance.
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