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Studies on Encapsulation of Bovine Serum Albumin, Lysozyme and Insulin Through Coaxial Electrospinning

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A single step method for encapsulation of clinically relevant proteins viz., Bovine Serum Albumin (BSA), Lysozyme and Insulin molecules, inside core-sheath structured polymer fibres using coaxial electrospinning technique, is described. Transmission electron microscopic pictures show the formation of core-sheath structure. The secondary structure of the proteins was characterized through CD spectroscopy. The secondary conformation was retained with a minor decrease in β-conformation and an increase in the random and turn conformations after coaxial electrospinning. This method of encapsulation is simple and requires little or no harsh treatment of sensitive biomolecules like insulin. Thus, the core-sheath structure of the fibres might apparently help protect the biomolecules during and after electrospinning, in addition to providing a high interactive surface area for controlled release. This scheme will be suitable for applications in cell culture and tissue regeneration.
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Document Type: Research Article

Publication date: December 1, 2013

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  • Journal of Biomaterials and Tissue Engineering (JBT) is an international peer-reviewed journal that covers all aspects of biomaterials, tissue engineering and regenerative medicine. The journal focuses on the broad spectrum of research topics including all types of biomaterials, their properties, bioimplants and medical devices, biofilms, bioimaging, BioMEMS/NEMS, biosensors, fibers, tissue scaffolds, tissue engineering and modeling, artificial organs, tissue interfaces, interactions between biomaterials, blood, cells, tissues, and organs, regenerative medicine and clinical performance.
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