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A Novel Route to Polycaprolactone Scaffold for Vascular Tissue Engineering

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Polycaprolactone biocomposite scaffolds were prepared by a novel process of precoagulationevaporation and subsequent gelatin immobilization. Water was used as the additive for partial coagulation of the polycaprolactone-chloroform solution. The subsequent coating of the precoagulated solution on a glass surface followed by drying provided a tubular scaffold with regular porosity. The dried scaffolds were treated with carbon dioxide plasma in order to introduce functional groups for enhancing hydrophilicity of the scaffold. Subsequently, gelatin was immobilised on the scaffold by dip coating. Both chemical and morphological changes took place during plasma treatment and gelatin immobilization. The scaffolds were porous and turned out to be hydrophilic. The surfaces were characterized by scanning electron microscopy, atomic force microscopy, tensile measurements and contact angle measurements. These scaffolds were found to offer excellent surfaces for the growth of progenitor-derived endothelial cells.
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Keywords: CELL SEEDING; GELATIN; POLYCAPROLACTONE; PROGENITOR DERIVED ENDOTHELIAL CELLS; VASCULAR SCAFFOLD

Document Type: Research Article

Publication date: 01 June 2013

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  • Journal of Biomaterials and Tissue Engineering (JBT) is an international peer-reviewed journal that covers all aspects of biomaterials, tissue engineering and regenerative medicine. The journal focuses on the broad spectrum of research topics including all types of biomaterials, their properties, bioimplants and medical devices, biofilms, bioimaging, BioMEMS/NEMS, biosensors, fibers, tissue scaffolds, tissue engineering and modeling, artificial organs, tissue interfaces, interactions between biomaterials, blood, cells, tissues, and organs, regenerative medicine and clinical performance.
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