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In Vivo Dopamine Biosensor Based on Copper(I) Sulfide Functionalized Reduced Graphene Oxide Decorated Microelectrodes

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A novel dopamine biosensor based on carbon fiber microelectrodes (CFMEs) modified with copper(I) sulfide functionalized nanocomposites of the reduced graphene oxide (Cu2S/RGO) has been explored for the sensitive detection of dopamine and in vivo monitoring the neurotransmitters released by Drosophila's brain. The as-prepared Cu2S/RGO decorated microelectrodes were characterized by scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS), and cyclic voltammetry (CV). Our observations demonstrate that Cu2S/RGO-CFMEs exhibited excellent catalytic activity and high selectivity for dopamine with relatively low detection limit (24 nM), wide linear range (i.e., from 0.1–20 μM) and outstanding reproducibility. Furthermore, the as-prepared new dopamine biosensor with high sensitivity and good stability was readily used to detect the amount of dopamine in the brain of drosophila, indicating the potential and promising application in the in vivo measurement of neurotransmitters without other electrochemical interference such as histidine, ascorbic acid, uric acid, and others.
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Keywords: COPPER SULFIDE; CYCLIC VOLTAMMETRY; DOPAMINE; MICROELECTRODE; REDUCED GRAPHENE OXIDE

Document Type: Research Article

Publication date: July 1, 2018

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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