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A Bifunctional Scaffold for Tissue Regeneration and Photothermal Therapy

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Clinical treatment for cancer comprises surgical removal and chemo/radio-therapy. In general, surgical intervention causes large defects while chemo/radio-therapy brings drug resistance and long-term suffering to patients. Major challenges remain in developing a therapeutic platform for simultaneous cancer treatment and tissue regeneration. In this study, a bifunctional scaffold based on gold nanorods-conjugated bioactive glass ([email protected]) nanofibers was investigated for this purpose. Owing to gold nanoparticles anchored at the surface of nanofibers, the composite scaffold exhibits excellent photothermal effect. Under 808 nm near-infrared (NIR) irradiation for 5 minutes, the temperature of scaffold reaches ∼42.5 °C which induced more than 89.5% cancer cell death. Meanwhile, the scaffold can effectively promote the proliferation of epithelial cells by 270% after 72 h incubation, confirming its expected bioactivity. The findings suggested that the [email protected] scaffold holds a promise for localized photothermal therapy and tissue regeneration, which is specifically inspiring in treating tumor-induced defects.
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Document Type: Research Article

Publication date: April 1, 2018

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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