Skip to main content
padlock icon - secure page this page is secure

A Bifunctional Scaffold for Tissue Regeneration and Photothermal Therapy

Buy Article:

$106.64 + tax (Refund Policy)

Clinical treatment for cancer comprises surgical removal and chemo/radio-therapy. In general, surgical intervention causes large defects while chemo/radio-therapy brings drug resistance and long-term suffering to patients. Major challenges remain in developing a therapeutic platform for simultaneous cancer treatment and tissue regeneration. In this study, a bifunctional scaffold based on gold nanorods-conjugated bioactive glass ([email protected]) nanofibers was investigated for this purpose. Owing to gold nanoparticles anchored at the surface of nanofibers, the composite scaffold exhibits excellent photothermal effect. Under 808 nm near-infrared (NIR) irradiation for 5 minutes, the temperature of scaffold reaches ∼42.5 °C which induced more than 89.5% cancer cell death. Meanwhile, the scaffold can effectively promote the proliferation of epithelial cells by 270% after 72 h incubation, confirming its expected bioactivity. The findings suggested that the [email protected] scaffold holds a promise for localized photothermal therapy and tissue regeneration, which is specifically inspiring in treating tumor-induced defects.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: BIOACTIVE GLASS NANOFIBERS; GOLD NANOROD; TISSUE REGENERATION; TUMOR PHOTOTHERMAL THERAPY

Document Type: Research Article

Publication date: April 1, 2018

More about this publication?
  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more