Generation of a Graft versus Anticancer Immune Response Through Skin Allograft with Tumor
Effector memory T cells (TEM) are a subset of memory T cells which play an important role in stimulation of adaptive immunity. Although they are associated with multiple immune responses, the antitumor effect of TEM is not clearly understood. In this research, generation of anti-tumor
TEM was induced through skin allografts in C57BL/6 mice with B16 melanoma. We observed that the growth of tumor tissues in C57BL/6 mice treated with allografts was interrupted. Furthermore, the survival time for the treated mice was prolonged along with increased serum levels for CXCL9, CXCL10
and INF-γ. Additionally, the concentrations of TEM in the spleens, lymph nodes and tumor tissues were markedly elevated in allografts treated mice. The tumor cell proliferation and tissue growth were suppressed in C57BL/6 mice with B16 melanoma induced by allografts, upon tail
vein injection of purified TEM. These results demonstrate that skin allografts promote the generation of anti-tumor TEM in C57BL/6 mice with B16 melanoma, which emphasize the strong promise of TEM stimulation using allografts transplants in effective tumor immunotherapy.
Keywords: B16 MELANOMA; C57BL/6 MOUSE; EFFECTOR MEMORY T CELL; SKIN ALLOGRAFT; TUMOR IMMUNOTHERAPY
Document Type: Research Article
Publication date: 01 March 2018
- Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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