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Fluorogenic Disassembly of Self-Quenched Near-Infrared Nanoparticles Enables Matrix Metalloproteinase Detection

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There are few reports on the enzyme-controlled disassembly of self-quenched near-infrared (NIR) fluorescent nanoparticles that turn fluorescence on for specific detection/imaging of their activity in vitro and in vivo. Herein, we report the rational design of a new NIR probe 1 whose fluorescence signal was self-quenched upon reduction-controlled condensation and subsequent assembly of its nanoparticles (i.e., 1-NP). Subsequent disassembly of 1-NP by matrix metalloproteinase 2 (MMP-2) turned the fluorescence on. Employing this enzymatic strategy, we successfully applied 1-NP for NIR detection of MMP-2 in vitro and NIR imaging of MMP-2 activity in living cells. Moreover, we also applied 1-NP for specific NIR imaging of MMP-2 activity in MC38 tumors in nude mice. We envision that this NIR probe 1 might be further developed for tumor-targeted imaging in routine preclinical studies or even in patients in the future.
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Document Type: Research Article

Publication date: February 1, 2018

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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