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Transcytosis of Mesoporous and Hollow Silica Nanoparticles from Endothelial Cells to Cancer Cells

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Nanoparticles have been widely researched for delivering drugs into tumor tissue for increase of therapeutic effect and decrease of drug toxicity. Passive targeting via enhanced permeation and retention (EPR) effect and active targeting with conjugation of targeting ligands are considered as two mostly used targeting strategies for nanoparticles targeting. In this research, we found an alternative way for delivering of the nanoparticles without targeting ligands into tumor cells by transcytosis across endothelial cells. The endocytosis for PEGylated mesoporous and hollow silica nanoparticles (PEG-MHSNs) into human umbilical vein endothelial cells (HUVEC) was caveolae-mediated pathway, and that for two cancer cell lines HepG2 and U251 cancer cells was via clathrin-mediated pathway. Importantly, PEG-MHSNs could transcytose across HUVEC monolayer and endocytose into cancer cells. It may provide a promising pathway for drug delivery.
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Keywords: ENDOCYTOSIS; EPR EFFECT; SILICA NANOPARTICLE; TRANSCYTOSIS; TUMOR TARGETING

Document Type: Research Article

Publication date: August 1, 2017

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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