Effect of Silica Nanorattles on the Mucosal Function in Mice After Repeated Oral Exposure
The hollow mesoporous silica nanomaterials (MSNs) have been widely considered as one of the promising new generation drug carriers for great potential application in biomedicine. However, we still know little about the biological effects of these nanostructures after the repeated oral exposure, especially the intestinal function. Herein, the structural changes and mucosal immune function of the intestinal and the major organs in ICR mice are observed in detail after freely drinking the aqueous solution of SNs with the average size of 60 and 110 nm (SN-60 and SN-110) at the concentration of 0.02, 0.1 and 0.5 mg mL–1 for continuous 28 days. The duodenum villus fell away and the damage became more serious as the dose increased in the group of SN-60. An increase of mast cells was observed in the intestinal mucosa of the mice. The analysis of serum biochemical indexes and bio-transmission electron microscope (bio-TEM) shows that the liver is injured in the group exposed with SN-60 at a high dose. However, no obvious damage was observed for the main organs and the function of intestinal tract in the group at SN-110. We deemed that the small sized SNs can affect the mucosal function of the mice. As such, SN-110 is more biocompatibile than SN-60. These results are very important and helpful for developing the biocompatible drug delivery system based on MSNs for biomedical applications in the future.
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Document Type: Research Article
Publication date: August 1, 2017
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