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Nanomedicine-Augmented Cancer-Localized Treatment by 3D Theranostic Implants

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Recent advances in nanomedicine-based therapeutic platforms, which have catalyzed the generation of new therapeutic modalities for oncology, have attracted great attentions from the scientific community in recent years. However, on account of the intrinsic limitations of the low delivery efficiency for conventional cancer therapies and the unclear understanding of nano-bio interactions, oncological applications of nanomedicine for contemporary clinical translation still encounter difficulties, underscoring the need to rethink new theranosic platforms for desirable therapeutic outcome. In this review, we highlight the newly-emerged theranosic 3D implants (organic, inorganic and organic/inorganic hybrid 3D implants) based on nanomedicine for efficient localized cancer treatment, and provide an overview and deep discussion on the recent progresses in this field. The current challenges and future developments of nanomedicine-based 3D implants on combating cancer are also discussed for their further potential clinical translations. It is highly believed that these constructed multifunctional 3D theranostic implants will pave a new way for the efficient cancer therapy based on their high therapeutic outcome and reduced side effects.
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Keywords: CANCER; IMPLANT; LOCALIZED THERAPY; NANOMEDICINE; THERANOSTIC

Document Type: Review Article

Publication date: August 1, 2017

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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