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Fe–Cr–Nb–B Magnetic Nanoparticle Interaction with Human Mesenchymal and Stem Cells

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The use of materials at the nanoscale is currently of increasing interest for life sciences and medicine. Particularly, magnetic nanoparticles are investigated for a large array of applications for medical diagnostic and treatment. We have previously demonstrated that Fe–Cr–Nb–B ferromagnetic nanoparticles display heating properties that recommend them as potent agents for delivery of local hyperthermia for the treatment of solid tumors. Stem cell-mediated delivery represents a safe modality of targeting tumor sites. This study investigated the interaction of Fe–Cr–Nb–B nanoparticles with human bone marrow-derived mesenchymal stem cells and human fibroblasts. The results revealed that bare and chitosan-coated Fe–Cr–Nb–B are internalized by both cell types, can be detected up to 28 days inside the cells without signs of membrane disruption and do not display in vitro cytotoxicity. Moreover, particle internalization does not interfere with proliferative and differentiation potential (osteogenesis and adipogenesis), thereby demonstrating an unaltered cellular phenotype. Further investigation of the potential effect on cytoskeleton dynamics, and in inducing oxidative stress is required. Present results are encouraging for the design of a stem cell-mediated delivery of Fe–Cr–Nb–B magnetic nanoparticles to solid tumor sites for hyperthermia applications.
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Keywords: CYTOTOXICITY; DIFFERENTIATION; FIBROBLASTS; HYPERTHERMIA; MAGNETIC NANOPARTICLES; MESENCHYMAL STEM CELLS; PROLIFERATION

Document Type: Research Article

Publication date: July 1, 2017

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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