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Inhibition of Glioblastoma Cell Proliferation by Hyaluronan Synthesis Inhibiting Nanoparticles

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Delivering therapeutics to a brain tumor is a challenge because of the tightly regulated blood brain barrier (BBB) as well as the dense and sticky extracellular matrix (ECM) composed mainly of hyaluronan and proteoglycans, which play a major role in glioblastoma progression. Several strategies have been employed to treat brain tumors. Here, we utilize nanoparticles to cross the BBB and target the hyaluronan rich matrix to treat the glioblastoma. We have developed poly(lactic-co-glycolic acid) (PLGA) polymeric nanoparticles of around 180 nm in size, surface coated with ApoE-peptides to facilitate the BBB transport, and encapsulated with 4-methylumbelliferone (4-MU), a hyaluronan synthesis inhibitor with anticancer properties, to modulate the brain ECM and subsequently inhibit tumor growth with high therapeutic efficacy. Our results show that the ApoE coated 4-MU nanoparticles significantly inhibit glioblastoma tumor growth compared to 4-MU treatment alone.
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Keywords: BRAIN DELIVERY; EXTRACELLULAR MATRIX; HYALURONAN; INHIBITING; NANOPARTICLES

Document Type: Research Article

Publication date: July 1, 2017

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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