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New Epigallocatechin Gallate (EGCG) Nanocomplexes Co-Assembled with 3-Mercapto-1-Hexanol and β-Lactoglobulin for Improvement of Antitumor Activity

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(-)-Epigallocatechin-3-gallate (EGCG), as the major catechin in green tea, is a potent antioxidant with numerous reported health benefits such as anti-proliferative and pro-apoptotic effects. Nanovehicles for EGCG delivery can effectively improve its antioxidant capacity, absorbability and bioavailability in vivo. We used thermally modified β-lactoglobulin (β-Lg), 3-mercapto-1-hexanol (3MH) and EGCG to form stable co-assembled nanocomplexes (MEβ-NPs) with greater stability, sustained release and anticancer effects in vitro and in vivo than free EGCG. MEβ-NPs inhibited A375, Hep G2 and TE-1 tumor cell proliferation with 65.90%, 60.44% and 32.88% greater activity, respectively, than EGCG. MEβ-NPs with 100 mg EGCG/kg (3MH/EGCG/β-LG = 4:32:1) were not toxic to mice and inhibited implanted human melanoma A375 cell tumor growth by 57.78%, twice as effective as EGCG alone. Thus, MEβ-NPs have greater stability and antitumor activity than EGCG, with potential value for anticancer therapy.
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Keywords: 3-MERCAPTO-1-HEXANOL; EPIGALLOCATECHIN-3-GALLATE (EGCG); NANOCOMPLEXES; TUMOR INHIBITION; β-LACTOGLOBULIN

Document Type: Research Article

Publication date: July 1, 2017

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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