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High-Efficiency EpCAM/EGFR-PLGA Immunomagnetic Beads with Specific Recognition on Circulating Tumor Cells in Colorectal Cancer

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To investigate the separation efficiency of epithelial cell adhesion molecule (EpCAM) and epidermal growth factor receptor (EGFR) PLGA magnetic beads in colorectal cancer circulating tumor cells (CTCs) separation and identification. The carboxylic polylactic acid-glycolic acid (PLGA-COOH) and chitosan hexadecyltrimethylammonium (HQCMC) were used to encapsulate Fe3O4 magnetic nanoparticle, connect EpCAM antibody and EGFR antibody to prepare immunomagnetic beads (IMMS). The fresh blood of 35 cases of colorectal cancer patients was collected and detected. The CTCs captured by EpCAM immunomagnetic beads (EPM) and EGFR immunomagnetic beads (GPM) were counted by IMMS separation technology and compared with the patient's condition and the clinical pathological data. The results showed that the homemade EPM and GPM could effectively specific recognition and capture different colorectal cancer CTCs, which was matching with the clinical results. In addition, GPM captured CTCs were consistent with the detection results of EGFR gene mutation.
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Keywords: CIRCULATING TUMOR CELLS; COLORECTAL CANCER; EPIDERMAL GROWTH FACTOR RECEPTOR; EPITHELIAL CELL ADHESION MOLECULES; MAGNETIC MICROSPHERE

Document Type: Research Article

Publication date: July 1, 2017

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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