Skip to main content
padlock icon - secure page this page is secure

Extracellular miRNAs: Origin, Function and Biomarkers in Hepatic Diseases

Buy Article:

$106.65 + tax (Refund Policy)

MicroRNAs (miRNAs), a class of 19–24 nucleotides non-coding RNAs, regulate gene expression by inhibiting both translation and stability of specific mRNAs at the post-transcriptional level. The existence of miRNAs in a series of mammalian body fluids as extracellular nuclease-resistant entities, together with the aberrant expression of miRNAs during the occurrence and development of a wide range of diseases, triggers the possibility that miRNAs as promising noninvasive diagnostic biomarkers are applied to predict the pathological status of the body. However, the origin and biological function of extracellular miRNAs have not been systematically elucidated. In this review, we summarize the current literature on the biogenesis and post-transcriptional regulation of miRNAs, discuss available evidence regarding the possible origin and release of extracellular miRNAs, and collect novel views on their potentials as key mediators in cell–cell communication processes. Finally, we shed light on the accumulating knowledge about their utilities as diagnostic biomarkers in hepatic diseases.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics


Document Type: Review Article

Publication date: October 1, 2014

More about this publication?
  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more