Skip to main content
padlock icon - secure page this page is secure

Improved Biocompatibility of Poly(lactic-co-glycolic acid) and Poly-L-Lactic Acid Blended with Nanoparticulate Amorphous Calcium Phosphate in Vascular Stent Applications

Buy Article:

$106.87 + tax (Refund Policy)

Biodegradable polymers used as vascular stent coatings and stent platforms encounter a major challenge: biocompatibility in vivo , which plays an important role in in-stent restenosis (ISR). Co-formulating amorphous calcium phosphate (ACP) into poly(lactic-co-glycolic acid) (PLGA) or poly-L-lactic acid (PLLA) was investigated to address the issue. For stent coating applications, metal stents were coated with polyethylene-co-vinyl acetate/poly-n-butyl methacrylate (PEVA/PBMA), PLGA or PLGA/ACP composites, and implanted into rat aortas for one and three months. Comparing with both PEVA/PBMA and PLGA groups after one month, the results showed that stents coated with PLGA/ACP had significantly reduced restenosis (PLGA/ACP vs. PEVA/PBMA vs. PLGA: 21.24 ± 2.59% vs. 27.54 ± 1.19% vs. 32.12 ± 3.93%, P < 0.05), reduced inflammation (1.25 ± 0.35 vs. 1.77 ± 0.38 vs. 2.30 ± 0.21, P < 0.05) and increased speed of re-endothelialization (1.78 ± 0.46 vs. 1.17 ± 0.18 vs. 1.20 ± 0.18, P < 0.05). After three months, the PLGA/ACP group still displayed lower inflammation score (1.33 ± 0.33 vs. 2.27 ± 0.55, P < 0.05) and higher endothelial scores (2.33 ± 0.33 vs. 1.20 ± 0.18, P < 0.05) as compared with the PEVA/PBMA group. Moreover, for stent platform applications, PLLA/ACP stent tube significantly reduced the inflammatory cells infiltration in the vessel walls of rabbit iliac arteries relative to their PLLA cohort (NF-κB-positive cells: 23.31 ± 2.33/mm2 vs. 9.34 ± 1.35/mm2, P < 0.05). No systemic biochemical or pathological evidence of toxicity was found in either PLGA/ACP or PLLA/ACP. The co-formulation of ACP into PLGA and PLLA resulted in improved biocompatibility without systemic toxicity.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: AMORPHOUS CALCIUM PHOSPHATE; BIOCOMPATIBILITY; POLY(LACTIC-CO-GLYCOLIC ACID); POLY-L-LACTIC ACID

Document Type: Research Article

Publication date: June 1, 2014

More about this publication?
  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more