Recent Advances in the Nanotechnology-Based Drug Delivery of Silybin
Silybin is the main component of silymarin and is a polyphenolic bioactive natural product found in the milk thistle plant Silybum marianum. Silybin possesses many health-promoting benefits, such as antioxidation and anticancer. However, the benefits are curtailed by its extremely
poor water solubility. Consequently, the bioavailability and therapeutic effective of silybin is also limited. Nanotechnology is an available approach to solving these issues. Currently, nanosuspensions, micelles, nanoparticles, nano-emulsions, etc. are used to improve the in vitro
dissolution velocity and in vivo efficiency of silybin. The present work reviews the nanotechnology-based applications and developments on silybin production. Silybin can also be utilized as a reference for the production and development of other water-insoluble drug delivery systems.
Keywords: BIOAVAILABILITY; NANOPARTICLES; NANOSUSPENSIONS; NANOTECHNOLOGY; SILYBIN
Document Type: Review Article
Publication date: 01 April 2014
- Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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