Skip to main content
padlock icon - secure page this page is secure

PAMAM Dendrimer Generation 5–Pluronic F127 Nanofilm as a Matrix for Local Metronidazole Release

Buy Article:

$106.34 + tax (Refund Policy)

A series of dendrimer G5-pluronic F127 nanofilms (at 1:10, 1:20 and 1:30 mole ratios), loaded with various percent of metronidazole hydrochloride, were prepared by the drug deposition with/without gelatin coating. The nanostructural feature of dendrimer G5-pluronic F127 as a matrix for a sustained drug release was investigated by choosing metronidazole, an antibacterial and antiprotozoal drug as a model drug. The studies on surface morphology, polymer erosion and metronidazole release of the prepared nanofilms revealed unique surface morphology, low film erosion rate and long drug release time. The drug release and the erosion rate of nanofilm were slowed in acidic pH condition and the presence of saliva in medium. The nanofilm of G5-PF127 (1:30 mole ratio) coated with gelatin further prolonged metronidazole release showing G5-PF127 coated with 20% gelatin to be the best suited for a metronidazole release. The nanofilms were stable for up to 9 months at dried condition, while those stored at room temperature with 30% relative humidity were less stable. Our results show that PAMAM dendrimer G5–pluronic F127 nanofilm has a potential to erve as a matrix for the local drug delivery.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics


Document Type: Research Article

Publication date: July 1, 2013

More about this publication?
  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more