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A Berberine-Loaded Electrospun Poly-(ε-caprolactone) Nanofibrous Membrane with Hemostatic Potential and Antimicrobial Property for Wound Dressing

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In this study, a berberine-loaded electrospun poly-(ε-caprolactone) nano?brous membrane (B-NFM) was formulated. The B-NFM was composed of uniform nanofibers with the average diameter of 190±53 nm. Whole blood assay revealed that the B-NFM had higher absorption capacity than gauze wound dressing (GWD) and non-drug-loaded nanofibrous membrane (NFM). Hemostatic studies showed that the B-NFM was more efficient at promoting blood clotting than GWD and NFM. B-NFM was also demonstrated to possess broad-spectrum antimicrobial activity. Biocompatibility studies indicated that B-NFM had good compatibility with skin fibroblast cells. These results suggested that the B-NFM can promote in vitro hemostasis to minimize wound bleeding, absorb biofluid to provide a favorable environment, inhibit on-site microbial agents to prevent wound infection, and support skin cell growth to facilitate wound healing. These data highly suggest a potential clinical use of B-NFM as wound dressing material.
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Keywords: ANTIMICROBIAL; BERBERINE; HEMOSTATIC; MEMBRANE; NANOFIBERS; WOUND DRESSING

Document Type: Research Article

Publication date: July 1, 2013

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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