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Analysis of Nanoscale Protein Film Consisting of Lactoferrin/11-MUA Bilayers for Bioelectronic Device

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We fabricated and analyzed a nanoscale biofilm of human lactoferrin making use of 11-mercapto-undecanoic acid (11MUA) as chemical linker. The fabrication of the bimolecular/organic hetero monolayer (lactoferrin/11-MUA) on gold substrate was confirmed with Raman spectroscopy. Cyclic voltammetry (CV) was carried out to observe the electrochemical properties of the nanoscaled biofilm under various pH conditions and at different time intervals. The well-defined redox properties were observed, even in certain harsh pH conditions and after a long time, proving the stabilities of this biofilm. Atomic force microscopy (AFM) was further employed to confirm the retention time by investigating the morphology variety of the biofilm over time. All these results proved that, the proposed nanoscaled thin film composed of lactoferrin and 11-MUA is a powerful alternative for making bioelectronics devices.
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Document Type: Research Article

Publication date: May 1, 2013

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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