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Effect of Nanoscale-ZnO on the Mechanical Property and Biocompatibility of Electrospun Poly(L-lactide) Acid/Nanoscale-ZnO Mats

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Poly(L-lactide) acid (PLLA) was mixed with different content of nanoscale-ZnO (N-ZnO) and spun into nonwoven mats by electrospinning, the effects of the blending ratio of N-ZnO on mats morphology and mechanical properties were investigated. The prepared mats were characterized with infrared spectrometry (IR), Brunauer–Emmett–Teller (BET) surface area, the morphology and tensile test were investigated by scanning electron microscope (SEM) and electronic universal testing machine, respectively. The quantity of N-ZnO contained in mats was determinated by Na2 EDTA titration method, then the N-ZnO loading coefficient (%, NL) could be figured out. Infrared spectrometry showed that the electrospun PLLA/N-ZnO mats were prepared successfully. When the concentration of N-ZnO contained in the mats increased from 0 to 2% (w/v), the curves of stress–strain indicated that the elastic modulus of mats ranged among 5.16 to 15.59 MPa. In addition, the electrospun PLLA/N-ZnO exhibited lower cell proliferation for UE7T-13 cells than electrospun PLLA mats and control. The results presented that the N-ZnO added in the mats enhanced the toughness of PLLA/ZnO mats to some extent, though the biocompatibility of blends was not good.
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Keywords: BIOCOMPATIBILITY; ELECTROSPINNING; MECHANICAL PROPERTY; NANOSCALE-ZNO; POLY(L-LACTIDE ACID)

Document Type: Research Article

Publication date: March 1, 2013

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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