Skip to main content
padlock icon - secure page this page is secure

Biodegradable Solid Lipid Nanoparticle Flocculates for Pulmonary Delivery of Insulin

Buy Article:

$106.67 + tax (Refund Policy)

The aim of our study was to prepare and characterize biodegradable insulin-loaded solid lipid nanoparticles (Ins-SLNs) flocculates for the pulmonary delivery of Ins. The cationic Ins-SLNs and anionic Ins-SLNs were prepared by W/O/W emulsion technique, respectively. Then anionic Ins-SLNs were self-assembled into flocculates via electrostatic interactions with the oppositely surface charged cationic Ins-SLNs followed by lyophilized into dry powders. The maximal entrapment efficiency of cationic Ins-SLNs and anionic Ins-SLNs were 56.32±1.01% and 66.02±1.58%, respectively. Freeze-drying the Ins-SLNs flocculates yielded dry powders with desirable aerodynamic diameter of 2.04±0.17 μm and low bulk density of 0.06146±0.0045 g/cm3, suitable for inhalation. In addition, the flocculates showed high aerosolization efficiency (emitted fraction of 92.54±0.77% and respirable fraction of 66.89±3.02%). The in vivo study showed that Ins-SLNs flocculates could prolong hypoglycemic effect and a relative pharmacological bioavailability of 35.62±1.34% could be achieved after intratracheal instillation to diabetic rats at the dose of 8 IU/kg dosage. Therefore, the biodegradable SLN flocculates fabricated via charge interaction may provide a useful strategy to fabricate dry powder for pulmonary administration of protein therapeutics or antigens.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics


Document Type: Research Article

Publication date: October 1, 2012

More about this publication?
  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more