Polymeric Disinfectant Nanocapsules: Effect of Molecular Weight of Poly(methyl acrylate)
Poly(methyl acrylate) (PMA) of various weight average molecular weights (M¯w were synthesized via the iniferter route and applied for the encapsulation of disinfectant agent (chlorhexidine digluconate; CHD) by using the controlled precipitation technique. The encapsulation efficiency of CHDPMA nanocapsules suspended in cyclohexane increased from 70 to 100% when the M¯w of PMA increased from 40 K to 550 K. After redispersing the capsules into 0.5% w/v of sodium dodecyl sulphate aqueous solution, the maximum content of CHD in the nanocapsules remained >90%. Transmission electron micrographs showed the spherical nanocapsule with continuous intact shell.
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Document Type: Research Article
Publication date: August 1, 2010
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