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Enhanced Gene Delivery Using Biodegradable Poly(ester amine)s (PEAs) Based on Low-Molecular-Weight Polyethylenimine and Poly(-caprolactone)-Pluronic-Poly(-caprolactone)

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In this paper, the poly(ester amine)s (PEAs) were successfully prepared from low-molecularweight PEI (Mn = 2000) and Poly(-caprolactone)-poly(ethylene glycol)–poly(propylene glycol)– poly(ethylene glycol)–poly(-caprolactone) (PCFC) copolymers using isophorone diisocyanate (IPDI) as cross-linker. The obtained PEAs copolymers are biodegradable and water-soluble. The PEAs/DNA complexes showed effective and stable DNA condensation with the particle size ≤200 nm and zeta potential ≥10 mV, indicating its potential for intracellular delivery. Compared to the unmodified low-molecular-weight PEI, PEAs displayed similarly low cytotoxicity in all two cell lines (293T: Human kidney carcinoma, HUVEC: Human umbilical vein Endothelial cell) and revealed much higher transfection efficiency in 293T cell lines. Therefore these PEAs might be a novel safe and efficient polymeric gene delivery vectors.
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Keywords: COPOLYMER; GENE DELIVERY SYSTEM; POLY(ESTER AMINE); POLY(-CAPROLACTONE)-PLURONIC; POLYETHYLENEIMINE

Document Type: Research Article

Publication date: August 1, 2010

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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