Preparation of Magnetic Microspheres Based on Poly(-Caprolactone)-Poly(Ethylene Glycol)Poly(-Caprolactone) Copolymers by Modified Solvent Diffusion Method
Magnetic microspheres have promising application in biomedical field. In this paper, biodegradable poly(-caprolactone)-poly(ethylene glycol)-poly(-caprolactone) (PCEC) triblock copolymers were synthesized by ring-opening polymerization method. Through adjusting the -CL/PEG weight ratio in feed, PCEC copolymers with different block ratio were obtained. A novel modified solvent diffusion method was described to prepare magnetic PCEC composite microspheres containing magnetite nanoparticles. The particle size of microsphere decreased with increase in the PEG/PCL block ratio. The obtained microspheres could response to external magnetic field. This study described a novel method to prepare magnetic microspheres. The obtained magnetic polymeric microspheres might have potential application in drug delivery system or disease diagnosis field.
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Document Type: Research Article
Publication date: June 1, 2010
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