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Preparation of Magnetic Microspheres Based on Poly(-Caprolactone)-Poly(Ethylene Glycol)Poly(-Caprolactone) Copolymers by Modified Solvent Diffusion Method

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Magnetic microspheres have promising application in biomedical field. In this paper, biodegradable poly(-caprolactone)-poly(ethylene glycol)-poly(-caprolactone) (PCEC) triblock copolymers were synthesized by ring-opening polymerization method. Through adjusting the -CL/PEG weight ratio in feed, PCEC copolymers with different block ratio were obtained. A novel modified solvent diffusion method was described to prepare magnetic PCEC composite microspheres containing magnetite nanoparticles. The particle size of microsphere decreased with increase in the PEG/PCL block ratio. The obtained microspheres could response to external magnetic field. This study described a novel method to prepare magnetic microspheres. The obtained magnetic polymeric microspheres might have potential application in drug delivery system or disease diagnosis field.
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Keywords: COPOLYMER MICROSPHERES; MAGNETIC PARTICLES; PCEC; PHASE TRANSITION; SOLVENT DIFFUSION

Document Type: Research Article

Publication date: June 1, 2010

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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