Skip to main content
padlock icon - secure page this page is secure

Extraction Issues of Paclitaxel in Nanocrystals

Buy Article:

$106.65 + tax (Refund Policy)

Nano-carrier systems have become an attractive alternative in the formulation of hydrophobic drugs, and the number of scientific and patent publications per year on nanoparticles has experienced exponential growth since 2000. As these drugs are carried by different nano-carriers, their pharmacokinetics (PK) and biodistribution will be greatly affected. Therefore, PK and biodistribution have become important parameters to evaluate the nano-systems, which are commonly performed by HPLC. This study looks at certain issues in extraction and HPLC analysis encountered in conducting biodistribution studies for paclitaxel (PTX) nanocrystals. We report here for the first time that the extraction efficiency of PTX depends on the nano-carriers, i.e., nanocrystals and nanomicelles. A selected solvent had to be added prior to extraction to totally destruct the nano-carrier structure to resolve this difference. It was also found that the extraction recovery of PTX carried by the nanocrystals was organ specific. Therefore, it will be critical to consider this difference when studying the distribution of drugs in nano-carriers. We hope that our findings would highlight certain issues to be aware of when conducting PK and biodistribution studies for nano-drug carriers.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: BIODISTRIBUTION; HPLC ANALYSIS; HPLC EXTRACTION; NANO-CARRIER SYSTEM; PACLITAXEL; PHARMACOKINETICS

Document Type: Short Communication

Publication date: April 1, 2010

More about this publication?
  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more