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Chitosan/Sodium Tripolyphosphate Nanoparticles: Preparation, Characterization and Application as Drug Carrier

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With the existence of amino groups, chitosan (CS) possesses positive charge, so it can self-assemble with tripolyphotspate (TPP) possessing negative charge via ionic gelation. We here synthesized CS/TPP nanoparticles, and then characterized it with the infrared spectra (IR) and scanning electron microscope (SEM) and transmission electron microscopy (TEM) and used bovine serum albumin (BSA) as a model drug to investigate sustained-release properties of CS/TPP nanoparticles. Infrared spectrum of CS/TPP nanoparticles indicated that CS was cross-linked with TPP. A homogeneous size distribution and good dispersion and micro-porous surface of CS/TPP nanoparticles were observed. The highest encapsulation efficiency (EE) of the BSA in CS/TPP nanoparticles prepared in different concentration of CS reached 79.74%, while BSA continually and smoothly released up to one week.
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Keywords: BSA; CHITOSAN; CONTROLLED RELEASE; NANOPARTICLES; TRIPOLYPHOTSPATE

Document Type: Research Article

Publication date: October 1, 2009

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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