Skip to main content
padlock icon - secure page this page is secure

Improvement on Synthesis of Different Alkyl-Phenylboronic Acid

Buy Article:

$106.23 + tax (Refund Policy)

Various alkyl-phenylboronic acids have been widely used in the fields of electronics, chemistry, medicine and biology, especially in glucose sensors and intermediates of medicines. In this paper, the syntheses of two or three different alkyl-phenylboronic acids and the improvement on synthesis processes were studied with Grignard reagent method in detail. The influencing factors such as temperature, reaction time, reactant molar ratio were analyzed with the orthogonal experiment; optimized processes for the preparation of different alkyl-phenylboronic acids were thus obtained using different alkylborates as original materials. Based on the analysis of the experiment results, a "one-pot" method was proposed and checked to synthesize several different alkyl-phenylboronic acids. It was shown that 2,6-dimethylphenylboronic acid could be synthesized with "one-pot" method while para-alkyl-phenylboronic acid could not. An optimized process for the synthesis of 2,6-dimethylphenylboronic acid was obtained by investigating the influence of the boronation reagent, reactant proportion and solvent on the yield. Meanwhile, the preliminary synthesis of 2-ethylphenylboric acid was investigated with "one-pot" method too. Each product was identified by mass spectrum, 1HNMR, IR and HPLC.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: "ONE-POT" METHOD; ALKYL-PHENYLBORONIC ACID; IMPROVEMENT; OPTIMIZED PROCESS; SYNTHESIS

Document Type: Research Article

Publication date: October 1, 2009

More about this publication?
  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more