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Analysis of Protein Physical Stability in Lipid Based Delivery Systems—The Challenges of Lipid Drug Delivery Systems

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Lipid based systems are a promising delivery system for many drug molecules, including labile compounds such as peptides and proteins. However, in the development of these systems the effect on the physical stability is rarely taken into account. Physical changes are often correlated with changes in biological activity but are generally much easier to assess. The present paper illustrates the use of a combination of techniques, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and intrinsic tryptophan fluorescence, to determine structural changes of proteins in lipid based systems such as solid lipid nanoparticles and emulsions.
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Keywords: DSC; FTIR; INTERFACES; LIPID BASED DRUG DELIVERY SYSTEMS; LYSOZYME; PEPTIDE; PROTEIN; PROTEIN PHYSICAL STABILITY; SLN; WATER-IN-OIL EMULSION

Document Type: Research Article

Publication date: August 1, 2009

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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