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A Potential Therapeutic Strategy for Diabetes and Its Complications in the Form of Co-Encapsulated Antioxidant Nanoparticles (NanoCAPs) of Ellagic Acid and Coenzyme Q10: Preparation and Evaluation in Streptozotocin Induced Diabetic Rats

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Diabetes is a metabolic disorder and is associated with serious complications caused by oxidative stress. The existing therapies only delay or reduce the severity of these complications but cannot completely prevent or reverse them. Antioxidant therapy is one promising alternative strategy to assuage these complications. However, the poor biopharmaceutical properties of many antioxidants limit their use as first line therapies. Here we propose a new therapeutic strategy to treat diabetes using biodegradable nano-co-encapsulated antioxidant particles (NanoCAPs) of ellagic acid (EA) and coenzyme Q10 (CoQ10). The combination of EA and CoQ10 showed beneficial effects in ameliorating lipid peroxidation, dyslipidemia and in preventing organ damage in streptozotocin induced diabetic rats. Significantly lower dose of EA and CoQ10 in NanoCAPs showed equal and sometimes more prominent results in comparison to simple suspension suggesting improved efficacy. Additionally, a statistically significant increase was observed in plasma insulin levels with nanoparticulate formulation of EA and CoQ10 combination in comparison to simple suspension of EA, CoQ10 alone or in combination as well as CoQ10 nanoparticles. Collectively, this data indicates the potential use of NanoCAPs of EA and CoQ10 in diabetes and reducing the associated complications.
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Keywords: ANTIOXIDANTS; COENZYME Q10; DIABETES; ELLAGIC ACID; NANOPARTICLES; OXIDATIVE DAMAGE

Document Type: Research Article

Publication date: March 1, 2008

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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