Skip to main content
padlock icon - secure page this page is secure

Preparation and Characterization of Novel Drug Delivery System of Light-Sensitive Silica Nanocapsules with Thin Shells

Buy Article:

$106.64 + tax (Refund Policy)

Nanoparticles and nanocapsules have emerged as versatile drug/gene carriers during the past decades. Furthermore, stimuli-responsive systems are developed whose properties change after exposure certain external triggers. Therefore, a triggered release of drugs from stimuli-sensitive nanoparticles and nanocapsules has become an interesting challenge in the pharmaceutical field. Light-sensitive core–shell nanoparticles of [email protected] with a diameter of approximately 45 nm and a silica shell thickness of within 5 nm were prepared using 40-nm diameter gold nanoparticles as templates. The light-sensitive molecules of vitamin C (Vc), 5(6)-carboxyfluorescein-N-hydroxysuccinimide ester (FLUOS), polyvinyl alcohol (PVA), and 2,5-dihydroxy-p-benzoquinone (DHBQ) were fabricated and embedded in silica shells. The mesoporous silica shells were controlled by regulating 3-aminopropyltrimethoxysilane (APS) addition because APS molecules can bind to gold nanoparticle surfaces at different percentages. Silica nanocapsules were prepared using sodium cyanide to dissolve gold cores. The morphology of [email protected] and silica nanocapsules was characterized by transmission electron microscopy (TEM). The dissolution time courses of prepared nanoparticles were investigated after irradiation with a superhigh-pressure mercury lamp (500 W). It was found that the silica shells became more condense and pore sizes shrunk after light sensitive molecules decomposed following light irradiation because the light-irradiated nanoparticles dissolved more slowly than the non-light-irradiated nanoparticles. From the TEM micrographs of silica nanocapsules, silica nanocapsule shrinking was also observed under high-density electron current. By our method, with a diameter of approximately 45 nm light-sensitive silica nanocapsules were obtained. These light-sensitive nanocapsules have high potential in future applications of the delivery of therapeutic drugs.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics


Document Type: Research Article

Publication date: March 1, 2008

More about this publication?
  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more