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Preparation and Characterization of Novel Drug Delivery System of Light-Sensitive Silica Nanocapsules with Thin Shells

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Nanoparticles and nanocapsules have emerged as versatile drug/gene carriers during the past decades. Furthermore, stimuli-responsive systems are developed whose properties change after exposure certain external triggers. Therefore, a triggered release of drugs from stimuli-sensitive nanoparticles and nanocapsules has become an interesting challenge in the pharmaceutical field. Light-sensitive core–shell nanoparticles of [email protected] with a diameter of approximately 45 nm and a silica shell thickness of within 5 nm were prepared using 40-nm diameter gold nanoparticles as templates. The light-sensitive molecules of vitamin C (Vc), 5(6)-carboxyfluorescein-N-hydroxysuccinimide ester (FLUOS), polyvinyl alcohol (PVA), and 2,5-dihydroxy-p-benzoquinone (DHBQ) were fabricated and embedded in silica shells. The mesoporous silica shells were controlled by regulating 3-aminopropyltrimethoxysilane (APS) addition because APS molecules can bind to gold nanoparticle surfaces at different percentages. Silica nanocapsules were prepared using sodium cyanide to dissolve gold cores. The morphology of [email protected] and silica nanocapsules was characterized by transmission electron microscopy (TEM). The dissolution time courses of prepared nanoparticles were investigated after irradiation with a superhigh-pressure mercury lamp (500 W). It was found that the silica shells became more condense and pore sizes shrunk after light sensitive molecules decomposed following light irradiation because the light-irradiated nanoparticles dissolved more slowly than the non-light-irradiated nanoparticles. From the TEM micrographs of silica nanocapsules, silica nanocapsule shrinking was also observed under high-density electron current. By our method, with a diameter of approximately 45 nm light-sensitive silica nanocapsules were obtained. These light-sensitive nanocapsules have high potential in future applications of the delivery of therapeutic drugs.
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Keywords: DISSOLUTION TIME COURSE; LIGHT-SENSITIVITY; NANOCAPSULES; SHELL SHRINKAGE; SILICA NANOCAPSULES

Document Type: Research Article

Publication date: March 1, 2008

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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