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Bioactive Mesoporous Silicas as Controlled Delivery Systems: Application in Bone Tissue Regeneration

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The biomedical scientific community is currently demanding new advances in nanoscience and nanotechnology for the design of third generation bioceramics that promote bone tissue regeneration. Nowadays, researchers aim the manufacture of scaffolds with 3D interconnected porosity and pores similar in size and number to those existing in the natural bone. Silica-based ordered mesoporous materials are excellent candidates to be used as starting materials for the further design and fabrication of scaffolds for bone tissue engineering. Mesoporous matrices can act as controlled delivery systems of osteogenic agents that promote bone formation. Moreover, these materials show bioactive behavior in contact with simulate body fluids, i.e., nano-sized apatite similar to that of natural bone is formed onto the material surfaces. This review deals with the recent scientific advances to enhance the potential applications of silica-based ordered mesoporous materials in bone tissue regeneration. The first approach consists in accelerating the bioactive response of these materials employing several chemical strategies, such as incorporating phosphorous into the silica network, adding small amounts of bioactive glasses or synthesizing bioactive ordered mesoporous glasses. The second approach concerns the technological advances developed to achieve a better control over the loading and release of biologically active molecules. This control can be achieved tailoring of the textural parameters and the chemical modification of the silica surface by organic functionalization.
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Keywords: BIOACTIVITY; BONE REGENERATION; CONTROLLED DELIVERY SYSTEMS; SCAFFOLDS; SILICA-BASED ORDERED MESOPOROUS MATERIALS

Document Type: Review Article

Publication date: March 1, 2008

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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