Anticancer Activities of Sparganium Stoloniferum on the Proliferation of MCF-7 Cells

The anticancer activities of Sparganium stoloniferum (SS) extracts on MCF-7 cells were studied. The effect of SS extract treatment on the MCF-7 cell proliferation, protein expression, cytotoxicity, and apoptosis were carried out. To assess the potential role of caspases in the process of apoptosis PARP cleavage was checked. The results showed that the SS extract inhibit the proliferation of breast cancer cells and the activation of caspases-3 was also increased in a time and dose dependent manner. The cleavage of the full-length PARP (116 kd) by caspase-3 have generated the 89-kd cleaved PARP fragment after the treatment and increasing the extract concentration from 1 to 2 mg/ml has significantly increased the caspase-3 induced PARP fragmentation.