Tc99m Doped Nano-Hematite for Lung Photoscintigraphy
Spherical hematite (α-Fe2O3) particles of 30 nm diameter are prepared using the force hydrolysis method and tagged with Tc99m to form a phosphor material for lung imaging in the photoscintigraphic method. The size and shape of hematite sol is evaluated using dynamic and static laser light scattering. Nanosized Tc99m-hematite particles are inhaled by human volunteers using the aerosol/nebuliser and imaging is carried out using gamma camera. Very low dose of the radioactive Tc99m is required (2 milirads) in aerosol/nebuliser method as compared to intravenous injection method (20 milirads). Tc99m have lesser half life compared to colloidal Au198 therefore Tc99m-α-Fe2O3 colloids are safer than Au198 colloids. Due to less retention time in lung (as compared to micro- or bigger particles) and very low concentrations (than recommended minimum of 11 mg/day for daily uptake of iron or LD50 (oral, rat) = 30 gm/kg for pulmonary carcinogens), nano-hematite particles may assimilate easily in blood and avoid post-diagnostic side effects. High surface area to volume ratio of nano-sized α-Fe2O3 is useful to improve the delivery and imaging efficiency of radioactive particles in lung.
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Document Type: Research Article
Publication date: December 1, 2005
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