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Tc99m Doped Nano-Hematite for Lung Photoscintigraphy

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Spherical hematite (α-Fe2O3) particles of 30 nm diameter are prepared using the force hydrolysis method and tagged with Tc99m to form a phosphor material for lung imaging in the photoscintigraphic method. The size and shape of hematite sol is evaluated using dynamic and static laser light scattering. Nanosized Tc99m-hematite particles are inhaled by human volunteers using the aerosol/nebuliser and imaging is carried out using gamma camera. Very low dose of the radioactive Tc99m is required (2 milirads) in aerosol/nebuliser method as compared to intravenous injection method (20 milirads). Tc99m have lesser half life compared to colloidal Au198 therefore Tc99m-α-Fe2O3 colloids are safer than Au198 colloids. Due to less retention time in lung (as compared to micro- or bigger particles) and very low concentrations (than recommended minimum of 11 mg/day for daily uptake of iron or LD50 (oral, rat) = 30 gm/kg for pulmonary carcinogens), nano-hematite particles may assimilate easily in blood and avoid post-diagnostic side effects. High surface area to volume ratio of nano-sized α-Fe2O3 is useful to improve the delivery and imaging efficiency of radioactive particles in lung.
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Document Type: Research Article

Publication date: December 1, 2005

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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