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Effects of Ergosterone on Alcohol-Induced Liver Disease and NLRP3 Signaling Pathway in Mice

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The health problem of alcoholism is global, and acute alcoholism can cause liver damage. This research was designed to assess the protective action of ergosterone on ALD. C57BL/6 mice were given ergosterone for 10 days and given two doses of 50% alcohol for 1 hour. AST, ALT, γ-GT, TNF-α, IL-18 and IL-1β levels in liver tissue or serum were measured by ELISA. HE was used to observed pathological changes of liver tissue and western blot was used to study NLRP3, ASC, pro-caspase-1, caspase-1, pro-IL-1β and IL-1β proteins levels in liver tissue. Results indicated that ergosterone pretreatment can apparently inhibit the alcohol-induced increase of AST, ALT, γ-GT, TNF-α, IL-18 and IL-1β levers in liver tissue or serum, and significantly inhibit the activation of NLRP3 induced by alcohol. The results indicated that ergosterone has a significant protective action on ALD, and may improve pathology by inhibiting NLRP3 signaling pathway activation.
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Keywords: ALCOHOL; ERGOSTERONE; LIVER INJURY; NLRP3 PATHWAY

Document Type: Research Article

Publication date: December 1, 2020

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