Effects of Ergosterone on Alcohol-Induced Liver Disease and NLRP3 Signaling Pathway in Mice
The health problem of alcoholism is global, and acute alcoholism can cause liver damage. This research was designed to assess the protective action of ergosterone on ALD. C57BL/6 mice were given ergosterone for 10 days and given two doses of 50% alcohol for 1 hour. AST, ALT, γ-GT, TNF-α, IL-18 and IL-1β levels in liver tissue or serum were measured by ELISA. HE was used to observed pathological changes of liver tissue and western blot was used to study NLRP3, ASC, pro-caspase-1, caspase-1, pro-IL-1β and IL-1β proteins levels in liver tissue. Results indicated that ergosterone pretreatment can apparently inhibit the alcohol-induced increase of AST, ALT, γ-GT, TNF-α, IL-18 and IL-1β levers in liver tissue or serum, and significantly inhibit the activation of NLRP3 induced by alcohol. The results indicated that ergosterone has a significant protective action on ALD, and may improve pathology by inhibiting NLRP3 signaling pathway activation.
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Document Type: Research Article
Publication date: December 1, 2020
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