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Synthesis, Characterization and Biological Activity Studies on 6-Alkyl-5,6-Dihydrobenzoimidazo [1,2-c]Quinazoline Derivatives

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Reaction of aminophenyl benzimidazole with propionaldehyde, i-butyraldehyde and i-valeraldehyde in alcohol resulted in the ethyl, isopropyl and isobutyl derivatives (I, II and III) of dihydrobenzoimidazo[1,2-c] quinazoline, respectively. All the products were characterized by elemental analysis, IR, UV-Vis, 1H NMR, 13C NMR and X-ray crystal structure analysis. The antimicrobial activities of these compounds against four bacterial strains (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas) and two fungal strains (Cryptococcus neoformans and Candida albicans) were evaluated. Compounds I and III crystallized in the orthorhombic Pna21 space group whereas the compound II crystallized in the monoclinic P21/c space group. The structures I, II and III were solved and refined to R-values of 0.0336, 0.0353 and 0.0387 respectively. A comparative study of the crystal structures of these compounds is also given in this paper.
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Keywords: ANTIMICROBIAL ACTIVITY; BENZIMIDAZOQUINAZOLINE DERTIVATIVES; NMR; XRD

Document Type: Research Article

Publication date: September 1, 2015

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  • Journal of Advanced Physics is an interdisciplinary peer-reviewed journal consolidating research activities in all experimental and theoretical aspects of advanced physics. The journal aims in publishing articles of novel and frontier physics that merit the attention and interest of the whole physics community. JAP publishes review articles, full research articles, short communications of important new scientific and technological findings in all latest research aspects of physics.
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