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Factors Associated with Failure of Conversion Among Tuberculosis Patients

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Background: Mycobacterium tuberculosis is a bacterium that causes pulmonary tuberculosis. Pulmonary tuberculosis is still a health problem in Indonesia. One of the tuberculosis control program evaluation is by looking at the results of the conversion after intensive treatment that is 80%. The conversion rate in Semarang during the last four years is still below the target. The study was aimed to identify risk factors related to the conversion failure acid-fast bacilli (AFB) smear positive in Semarang. Method: A case-control study design using data from the TB-03 form in all health center in Semarang City (37 HC) and interview the respondents were already taking medicine for two months since the diagnosis of tuberculosis. The subjects were 51 cases (smear is still positive after the intensive phase) and 51 controls (smear negative after the intensive phase of treatment). Results: Most of the conversion failure occurred most in the age range 50–54 years (19.6%), the majority of work was private employees (33.33%). Risk factors that statistically significant related to the sputum conversion failure are attitude (OR 4.8; CI95% = 1.2 to 19.1), regularly take medication (OR 8; CI95% = 2.6 to 24.5), how to take medication (OR 4; CI95% = 1.3 to 12.5), nutritional status (OR 5.8; CI95% = 1.8 to 17.9), and DOTS (Directly Observed Treatment Shortcourse) program (OR 3.3; CI95% = 1.2 to 9.5). Conclusion: The incidence of pulmonary tuberculosis conversion failure influenced by the attitude of the patient, regularity of taking medication, how to take the medicine, nutritional status and support from medication home-based supervisor.
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Keywords: Conversion Rate; Failure; Sputum; Tuberculosis

Document Type: Research Article

Affiliations: Faculty of Public Health, Diponegoro University, Semarang, 50275, Central Java, Indonesia

Publication date: April 1, 2017

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