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Diagnosis of Dengue Hemorrhagic Fever Based on Laboratory Test of Serology and PCR from Suspected Patients in Hospital

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Background: DHF (Dengue Hemorrhagic Fever) still become one of the health problems in Indonesia. Incidence rate of DHF was higher than 20 per 100.000 population. The clinical symptoms were not specific anymore. The aim of this study was to compare the sensitivity and specificity of DHF diagnosis between serology and PCR test. Method: This study was a descriptive observational using cross sectional approach. Twenty four patients of suspect DHF in a hospital in Semarang were recruited. Diagnosis was based on a rapid test which usually done in Hospital, and then the results were compared to PCR technique. Data were analyzed descriptively. Result: The result showed that all of the subjects (24 patients) had thrombocytopenia ≤150,000 cells/mm3. The number of males and females are equal 50%, the mean of age were 35.4 year old, and 36.4% of them were unemployed. This study found that IgM positivity were 50% (primer infection), and IgG were 37,5% (secondary infection). Based on PCR tests to the subjects, 35% positivity were found and 42,9% Den-3 strain were detected. One patient had mixed infection of Den-2 and Den-4. Conclusion: There was a difference in diagnosis between clinical symptoms and laboratory tests.
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Keywords: Dengue Hemorrhagic Fever (DHF); IgM; PCR; Serology

Document Type: Research Article

Affiliations: 1: Public Health Faculty of Diponegoro University, Professor Soedarto, SH., Tembalang, Semarang, 50239, Indonesia 2: Science and Mathematic Faculty of Diponegoro University, Professor Soedarto, SH., Tembalang, Semarang, 50239, Indonesia

Publication date: April 1, 2017

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  • ADVANCED SCIENCE LETTERS is an international peer-reviewed journal with a very wide-ranging coverage, consolidates research activities in all areas of (1) Physical Sciences, (2) Biological Sciences, (3) Mathematical Sciences, (4) Engineering, (5) Computer and Information Sciences, and (6) Geosciences to publish original short communications, full research papers and timely brief (mini) reviews with authors photo and biography encompassing the basic and applied research and current developments in educational aspects of these scientific areas.
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