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The Effect of Selenium Supplementation on Hemoglobin Among Farmers Working as Pesticide Sprayers

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Background: The symptom of organophosphate (OPs) poisoning develops when the activity of cholinesterase enzyme (ChE) at the nerves ending is obstructed, which caused accumulation of ACh in the nerve endings. The returning of ChE to the normal levels depends on the ability of Erythrocyte cell membrane to survive from lipid peroxidation, with the help of Glutathione peroxides enzyme (GPX), which is heavily depend on Selenium (Se). This study aimed to find out the benefits of Selenium and Vitamin C supplementation on Hemoglobin levels of the farmers working as pesticide sprayers. Method: This was an experimental study using Pre and post test Control Group Design. Ninety nine farmers lived in Pasuruan village, Temanggung, Central Java who fulfilled the inclusion and exclusion criteria were selected as the subjects. Se and Vit C supplementation were given for 7 consecutive days. Results: The hemoglobin levels in Selenium group increased by 2.66%, while in the control group and the group receiving Se + Vit C decreased by 1.96% (p = 0.0001). Conclusion: Supplementation of Selenium 200 μg for 7 consecutive days would increase the hemoglobin level of pesticide sprayers-farmers.
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Keywords: Experimental Study; Level of Hemoglobin; Selenium; Vitamin C

Document Type: Research Article

Affiliations: 1: Department of Occupational Health and Safety, Faculty of Public Health, Diponegoro University, Jl. Prof. Soedarto, SH, Tembalang, Semarang 50275, Indonesia 2: Department of Environmental Health, Faculty of Public Health, University of Indonesia, Jl. Lingkar Kampus Raya Universitas Indonesia, Depok 16424, Indonesia 3: Faculty of Health Sciences, Universitas Jenderal Soedirman, Purwokerto, Indonesia

Publication date: April 1, 2017

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