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Enhanced Global Score Test for Multivariate Survival Analysis of Recurrent Events Data

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Multiple event times or endpoints often arise in survival data and this complicates analysis especially when all endpoints are of equal interest. However, to conclude on the overall treatment advantage of a new drug, a single statistic is required. The cumulative treatment advantage is often measured by the score statistic for each endpoint. This study is to enhance the methodology for combining multiple endpoints within a single statistical analysis. The correlations for three endpoints are determined and overall treatment advantage is evaluated. Comparison of the enhanced global score test method with that of the Wei, Lin and Weissfeld proves its suitability and adequacy as marginal model alternative solution.
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Keywords: Multivariate; Recurrent Events; Score Test; Survival Analysis

Document Type: Research Article

Affiliations: School of Quantitative Sciences, College of Arts and Sciences, Universiti Utara Malaysia, 06010 UUM Sintok, Kedah, Malaysia

Publication date: April 1, 2017

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  • ADVANCED SCIENCE LETTERS is an international peer-reviewed journal with a very wide-ranging coverage, consolidates research activities in all areas of (1) Physical Sciences, (2) Biological Sciences, (3) Mathematical Sciences, (4) Engineering, (5) Computer and Information Sciences, and (6) Geosciences to publish original short communications, full research papers and timely brief (mini) reviews with authors photo and biography encompassing the basic and applied research and current developments in educational aspects of these scientific areas.
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