The Interface Nonplanarity Investigated by the Surface Plasmon Resonance Imaging
Surface plasmon resonance imaging (SPRi) sensors realize highly sensitive, real-time, quantitative, label-free, high-throughput biological interaction monitoring and the binding profiles from multi-analytes. Further provide the binding kinetic parameters between different biomolecules. With such a sensitive method it is very important to point the need for planarity and homogeneity of the entire biochip for a correct output data. This paper is based on experimental SPRi data from our commercial device GenOptics SPRI-Lab+ measured at biochip with Kretschmann configuration. Initial processing of calibration data shows significant variations in the resonance angle across the active layer of the biochip. Here we analyze in detail the possible reasons for observed inhomogeneity, which has a great influence on the operation of the device.
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Document Type: Research Article
Publication date: March 1, 2016
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