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Contrast-Controlled Retinal Response as a Biomarker for a Glaucomatous Eye

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When the entry of a light beam through a pupil is gradually shifted from the centre toward its periphery Stiles Crawford reduction in visibility is observed. In addition, the retinal visibility can also be governed by generating an interference pattern on the retina. In the present analysis, the dependence of visibility on both pupil entry point, and the contrast of the interference pattern are taken as the basis for a biomarker in the early detection of glaucomatous damage to vision. Our approach in this study consists in finding a theoretical contrast dependent visibility function, relating the visibility function to visual field loss in a glaucomatous eye and predicting the visual field loss in a glaucoma eye from the contrast threshold elevation in the visibility function. The theoretical technique employed here is intended to generate an interference pattern of 0.5 contrast on the retina for fixed pupil entry point of 3.5 mm and raise the contrast threshold elevation in step of 0.01 to restore back the visibility loss to the standard 37%. It is found that on an average 0.01 contrast threshold elevation is associated with nearly 1% visual field loss for a glaucoma eye.
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Keywords: BIOMARKER; CONTRAST THRESHOLD; GLAUCOMA; STILES CRAWFORD EFFECT

Document Type: Research Article

Publication date: February 1, 2016

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  • ADVANCED SCIENCE LETTERS is an international peer-reviewed journal with a very wide-ranging coverage, consolidates research activities in all areas of (1) Physical Sciences, (2) Biological Sciences, (3) Mathematical Sciences, (4) Engineering, (5) Computer and Information Sciences, and (6) Geosciences to publish original short communications, full research papers and timely brief (mini) reviews with authors photo and biography encompassing the basic and applied research and current developments in educational aspects of these scientific areas.
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